Striatal dopamine transporter in different disability stages of Parkinson's disease studied with [123I]β-CIT SPECT
Identifieur interne : 002224 ( Main/Exploration ); précédent : 002223; suivant : 002225Striatal dopamine transporter in different disability stages of Parkinson's disease studied with [123I]β-CIT SPECT
Auteurs : Juha O. Rinne [Finlande] ; Jyrki T. Kuikka [Finlande] ; Kim A. Bergström [Finlande] ; Urpo K. Rinne [Finlande]Source :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1995.
Abstract
Six healthy controls and eighteen patients with Parkinson's disease in different disability stages were studied with SPECT using [123I]β-CIT to label the striatal dopamine transporter. The mean uptake of [123I]β-CIT in the putamen was reduced to 54% of the control mean and to 65% of the average control value in the caudate nucleus. In patients with totally, or predominantly unilateral symptoms the reduction was greater on the side opposite to the predominant symptoms (to 56% of the control mean in the contralateral putamen and to 77% in the ipsilateral putamen). There was a significant negative correlation between [123I]β-CIT uptake in the putamen and the Hoehn and Yahr stage (r = -0.81, p < 0.0001). An analysis of covariance was performed using age and disease duration as covarianes, and the correlation between putaminal [123I]β-CIT uptake and parkinsonian disability according to the Hoehn and Yahr stage remained significant (r = -0.75, p = 0.02). A similar correlation was seen in the caudate nucleus (r = −0.79, p < 0.0001) between the uptake of [123I]β-CIT and the Hoehn and Yahr stage. The correlation also remained significant after correction for the duration of disease and age of the patients (r= -0.76, p = 0.02). The present results show that [1231],Q-CIT SPECT is a useful method to study the function of presynaptic dopaminergic terminals in PD, and might be used in the early diagnosis and follow-up of the disease.
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DOI: 10.1016/1353-8020(95)00012-U
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The mean uptake of [123I]β-CIT in the putamen was reduced to 54% of the control mean and to 65% of the average control value in the caudate nucleus. In patients with totally, or predominantly unilateral symptoms the reduction was greater on the side opposite to the predominant symptoms (to 56% of the control mean in the contralateral putamen and to 77% in the ipsilateral putamen). There was a significant negative correlation between [123I]β-CIT uptake in the putamen and the Hoehn and Yahr stage (r = -0.81, p < 0.0001). An analysis of covariance was performed using age and disease duration as covarianes, and the correlation between putaminal [123I]β-CIT uptake and parkinsonian disability according to the Hoehn and Yahr stage remained significant (r = -0.75, p = 0.02). A similar correlation was seen in the caudate nucleus (r = −0.79, p < 0.0001) between the uptake of [123I]β-CIT and the Hoehn and Yahr stage. The correlation also remained significant after correction for the duration of disease and age of the patients (r= -0.76, p = 0.02). The present results show that [1231],Q-CIT SPECT is a useful method to study the function of presynaptic dopaminergic terminals in PD, and might be used in the early diagnosis and follow-up of the disease.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></region><name sortKey="Bergstrom, Kim A" sort="Bergstrom, Kim A" uniqKey="Bergstrom K" first="Kim A." last="Bergström">Kim A. Bergström</name><name sortKey="Kuikka, Jyrki T" sort="Kuikka, Jyrki T" uniqKey="Kuikka J" first="Jyrki T." last="Kuikka">Jyrki T. Kuikka</name><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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